Snake (Walterinnesia aegyptia) venom-loaded chitosan nanoparticles induce apoptosis and growth arrest in human breast cancer cells

Supervisor

Dr. Ahmed Sadek

Researchers

Noha Amer

Heba Karmy

Habiba Sherif

Aim

In this study, the aim is to evaluate the impact of WEV alone and WEV+NP on the migration, invasion, proliferation and apoptosis of breast cancer cell line by using a CFSE proliferation assay. Furthermore, analysis of the cell cycle to indicate if the WEV+NP will alter the cell cycle of breast cell line and enhanced the induction of apoptosis or not. And then detection of some angiogenesis factors such as (VEGF) which is the main regulatory factor involved in tumor angiogenesis to know if there's any change that occurred.

Progress

The team of researchers started by deepening their knowledge into the field of nanotechnology by reading and presenting their findings. Weekly meetings with the supervisor to further accelerate the work. Few weeks later they have reached a solid background of information regarding both the venoms and the application of nanotechnology. During the holly month of Ramadan the progress hasn't stopped they have been given trainings and simulations on the practical work and have designed their experimental design.