Course Description

Bioinformatics is a blend of multiple areas of study including biology, data science, mathematics and computer science. The field focuses on extracting new information from massive quantities of biological data and requires that scientists know the tools and methods for capturing, processing and analyzing large data sets. Bioinformatics scientists analyze DNA sequence alignment to find mutations and anomalies and understand the impact on cellular processes. The bioinformatician uses software to analyze protein structure and its impact on cell function. Learning how to design experiments and perform advanced statistical analysis is essential for anyone interested in this field.

Course Structure

• Bioinformatics, Identification and usage

• Library of information (databases)

• NCBI vs. EMBl-ENA (database navigation) 

• Blast and MSA ( parameters, analyzing results) and Phylogenetic tree building 

• Case study ( how to identify a fungus species?) 

• Tips and tricks to design the primers 

• Primer accessories ( RBS, Signaling peptides, fusion peptides, terminators) 

• Insert restriction sites identification

• Clone a gene on your PC 

• Protein structure, CDD search 

• Uniprot database navigation, identifying variations and mutagensis 

• non-coding DNA, is it useful?

• Introduction to dpSNP and Clinvar